000 03675nam a22004815i 4500
001 978-1-61779-391-2
003 DE-He213
005 20140220083251.0
007 cr nn 008mamaa
008 111102s2012 xxu| s |||| 0|eng d
020 _a9781617793912
_9978-1-61779-391-2
024 7 _a10.1007/978-1-61779-391-2
_2doi
050 4 _aRC648-665.2
072 7 _aMJG
_2bicssc
072 7 _aMED027000
_2bisacsh
082 0 4 _a616.4
_223
100 1 _aSima, Anders A.F.
_eeditor.
245 1 0 _aDiabetes & C-Peptide
_h[electronic resource] :
_bScientific and Clinical Aspects /
_cedited by Anders A.F. Sima.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2012.
300 _aXIII, 169 p. 63 illus., 35 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aContemporary Diabetes
505 0 _aPreface -- Foreword -- C-peptide and Insulin – A Happy Marriage -- Peptide Interactions of Proinsulin C-peptide -- he Effect of Combined C-peptide and Zinc on Cellular Function -- C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy -- Role of C-Peptide in the Regulation of Microvascular Blood Flow -- Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy? -- Renoprotective Effects of C-Peptide in Type I Diabetes -- The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic Neuropathy -- C-peptide and Type 1 Diabetic Encephalopathy -- C-peptide: a New Molecule with Anti-Inflammatory Properties -- C-peptide: Connecting Diabetes with Macrovascular Complications -- C-peptide and Diabetic Neuropathy in Patients with Type I Diabetes -- Proatherogenic Effects of C-Peptide -- Conclusions and Future Outlook.
520 _aIn Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide’s physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.
650 0 _aMedicine.
650 0 _aInternal medicine.
650 0 _aDiabetes.
650 0 _aEndocrinology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aEndocrinology.
650 2 4 _aDiabetes.
650 2 4 _aInternal Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781617793905
830 0 _aContemporary Diabetes
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-61779-391-2
912 _aZDB-2-SME
999 _c101601
_d101601