000			03633nam a22005175i 4500
001			978-1-61779-358-5
003			DE-He213
005			20140220083251.0
007			cr nn 008mamaa
008			111101s2012 xxu| s |||| 0|eng d
020			_a9781617793585 _9978-1-61779-358-5
024	7		_a10.1007/978-1-61779-358-5 _2doi
050		4	_aRB1-214
072		7	_aMMF _2bicssc
072		7	_aMED067000 _2bisacsh
082	0	4	_a616.07 _223
100	1		_aRusso, Antonio. _eeditor.
245	1	0	_aDiagnostic, Prognostic and Therapeutic Value of Gene Signatures _h[electronic resource] / _cedited by Antonio Russo, Stefano Iacobelli, Juan Iovanna.
250			_a1.
264		1	_aTotowa, NJ : _bHumana Press, _c2012.
300			_aXI, 182p. 28 illus., 24 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Clinical Pathology
505	0		_aPreface -- Gene signatures and soft tissue sarcomas: status of art and perspectives -- Heterogeneity of breast cancer: gene signatures and beyond -- Gene signatures in CRC and liver metastasis -- Gene signatures in Gastrointestinal Stomal Tumors (GIST) -- Pancreatic Cancer Genetics -- Diagnostic, prognostic and therapeutic value of gene signatures in non-small-cell lung cancer -- Gene signatures in Gastric Cancer -- Gene signatures in Colorectal Cancer -- The role of epigenetics in cancer: from molecular function to high-throughput assays -- Primary Epithelial Ovarian Neoplasms:  New concepts concerning origin, pathogenesis and classification based on morphology, immunomarkers, molecular features and gene expression studies -- Thyroid carcinoma: molecular signature by histotype specific mutations and gene expression patterns.
520			_aGene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.   Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.   Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.
650		0	_aMedicine.
650		0	_aMedical laboratories.
650		0	_aOncology.
650		0	_aPathology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aPathology.
650	2	4	_aOncology.
650	2	4	_aLaboratory Medicine.
700	1		_aIacobelli, Stefano. _eeditor.
700	1		_aIovanna, Juan. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781617793578
830		0	_aCurrent Clinical Pathology
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-61779-358-5
912			_aZDB-2-SME
999			_c101599 _d101599