000			03838nam a22004815i 4500
001			978-1-60761-433-3
003			DE-He213
005			20140220083251.0
007			cr nn 008mamaa
008			111201s2012 xxu| s |||| 0|eng d
020			_a9781607614333 _9978-1-60761-433-3
024	7		_a10.1007/978-1-60761-433-3 _2doi
050		4	_aRB1-214
072		7	_aMMF _2bicssc
072		7	_aMED067000 _2bisacsh
082	0	4	_a616.07 _223
100	1		_aMurphy, Michael J. _eeditor.
245	1	0	_aDiagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma _h[electronic resource] / _cedited by Michael J. Murphy.
264		1	_aNew York, NY : _bSpringer New York, _c2012.
300			_aXIV, 322p. 29 illus., 24 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Clinical Pathology
505	0		_aIntroduction to Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma -- Diagnostic and Prognostic Biomarkers in Melanoma: Current State of Play -- Molecular Pathogenesis of Melanoma: Established and Novel Pathways -- Staging of Melanoma -- Clinical and Histopathological Parameters in Melanoma -- Genetic/Epigenetic Biomarkers: Distinction of Melanoma from Other Melanocytic Neoplasms -- mRNA Biomarkers in Melanoma -- Epigenetic Biomarkers in Melanoma -- microRNA Biomarkers in Melanoma -- MicroRNAs as Biomarkers and Therapeutic Targets in Melanoma -- Mitochondrial DNA Biomarkers in Melanoma -- Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (A) Diagnosis -- Tissue-Based Protein Biomarkers in Melanoma: Immunohistochemistry: (B) Prognostication -- Tissue-Based Protein Biomarkers in Melanoma: Mass Spectrometry-Based Strategies -- Serological Biomarkers in Melanoma -- Molecular Markers of Lymph Node Disease in Melanoma -- Melanoma Cell Propagation: Cancer Stem Cell, Clonal Evolution and Interconversion Models of Tumorigenicity -- Surgical Management of Melanoma: Concept of Field Cancerization and Molecular Evaluation of Tissue Margins -- Chemotherapy for Melanoma -- Molecular-Targeted Therapy for Melanoma -- Anti-Angiogenesis Therapy for Melanoma -- Immunological Biomarkers and Immunotherapy for Melanoma -- Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma: An Overview.
520			_aThis book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.
650		0	_aMedicine.
650		0	_aDermatology.
650		0	_aOncology.
650		0	_aPathology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aPathology.
650	2	4	_aOncology.
650	2	4	_aDermatology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781607614326
830		0	_aCurrent Clinical Pathology
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-60761-433-3
912			_aZDB-2-SME
999			_c101562 _d101562