000 02777nam a22004335i 4500
001 978-1-4614-5398-7
003 DE-He213
005 20140220083250.0
007 cr nn 008mamaa
008 130730s2012 xxu| s |||| 0|eng d
020 _a9781461453987
_9978-1-4614-5398-7
024 7 _a10.1007/978-1-4614-5398-7
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aMeroni, Germana.
_eeditor.
245 1 0 _aTRIM/RBCC Proteins
_h[electronic resource] /
_cedited by Germana Meroni.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2012.
300 _aXIX, 145 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598
505 0 _aGenomics and Evolution of the TRIM Gene Family -- The TRIpartite Motif: Structure and Function -- TRIM Proteins as RING Finger E3 Ubiquitin Ligases -- PML Nuclear Bodies and Other TRIM-Defined Subcellular Compartments -- TRIM Involvement in Transcriptional Regulation -- TRIM Proteins in Cancer -- TRIM Proteins and the Innate Immune Response to Viruses -- The Microtubule-Associated C-I Subfamily of Trim Proteins and the Regulation of Polarized Cell Responses -- MuRFs: Specialized Members of the TRIM/RBCC Family with Roles in the Regulation of the Trophic State of Muscle and Its Metabolism -- TRIM Proteins in Development.
520 _aThe genomic ‘golden age’ has delivered the sequence of numerous novel genes while leaving us with many unanswered questions about their function. This is particularly true for gene families as, often, members are annotated based on homology rather than function. The tripartite motif family belonged to this category, although, during the last few years, the field boosted an important wealth of biochemical, cellular and physiological breakthrough data. In the first part of this book, we attempt to offer an overview of state‑of‑the‑art basic findings on the tripartite motif (TRIM, also known as RBCC) family members and to deal in the second part with their relevant and growing physiological and pathological roles.
650 0 _aMedicine.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461453970
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-5398-7
912 _aZDB-2-SBL
999 _c101531
_d101531