000 02973nam a22005055i 4500
001 978-1-4614-4093-2
003 DE-He213
005 20140220083249.0
007 cr nn 008mamaa
008 120620s2012 xxu| s |||| 0|eng d
020 _a9781461440932
_9978-1-4614-4093-2
024 7 _a10.1007/978-1-4614-4093-2
_2doi
050 4 _aQH588.S83
072 7 _aPSAK
_2bicssc
072 7 _aSCI017000
_2bisacsh
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
100 1 _aYee-Ki, Lee.
_eauthor.
245 1 0 _aCalcium Handling in hiPSC-Derived Cardiomyocytes
_h[electronic resource] /
_cby Lee Yee-Ki, Siu Chung-Wah.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2012.
300 _aXII, 52 p. 18 illus., 17 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringerBriefs in Stem Cells,
_x2192-8118
505 0 _aCalcium is crucial in governing contractile activities of myofilaments in cardiomyocytes, any defeats in calcium homeostasis of the cells would adversely affect heart pumping action. The characterization of calcium handling properties in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMCs) is of significant interest and pertinent to the stem cell and cardiac regenerative field because of their potential patient-specific therapeutic use. Table of contents: Myocardial Infarction and Heart Failure -- Embryonic Stem Cells/ Pluripotent Stem Cells -- Human Induced Pluripotent Stem Cell (hiPSC)-derived Cardiomyocytes as a Source for Cardiac Regeneration -- Calcium Homeostasis in Cardiomyocytes -- Sarcoplasmic Reticulum (SR) Governs Maturity of Cardiomyocytes -- SR Junctional Proteins Play a Role in Calcium Flux Between Cytosol and SR -- Spatial and Temporal Ca2+ Wavefront Dictated by T-tubule Structure -- IP3-Mediated Calcium Release Contributes to Whole-Cell Calcium Transients -- Calcium Handling Properties of hES-derived Cardiomyocytes -- iPSC-derived Cardiomyocyte as A Potential Platform for Disease Modellig of Impaired Calcium-Handling Related Syndrome -- Measurement of Cytosolic [Ca2+] by Fluorescence Confocal Microscopy -- Excitation-Contraction (EC) Coupling Assessment -- Limitation and Future Studies.
520 _aNA
650 0 _aLife sciences.
650 0 _aCardiology.
650 0 _aCytology.
650 0 _aStem cells.
650 1 4 _aLife Sciences.
650 2 4 _aStem Cells.
650 2 4 _aCardiology.
650 2 4 _aCell Biology.
700 1 _aChung-Wah, Siu.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461440925
830 0 _aSpringerBriefs in Stem Cells,
_x2192-8118
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4093-2
912 _aZDB-2-SBL
999 _c101478
_d101478