000 04466nam a22004935i 4500
001 978-1-4614-3828-1
003 DE-He213
005 20140220083249.0
007 cr nn 008mamaa
008 120713s2012 xxu| s |||| 0|eng d
020 _a9781461438281
_9978-1-4614-3828-1
024 7 _a10.1007/978-1-4614-3828-1
_2doi
050 4 _aQD96.M3
072 7 _aPNFS
_2bicssc
072 7 _aSCI078000
_2bisacsh
082 0 4 _a543.65
_223
100 1 _aXu, Q. Alan.
_eeditor.
245 1 0 _aLC-MS in Drug Bioanalysis
_h[electronic resource] /
_cedited by Q. Alan Xu, Timothy L. Madden.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Springer,
_c2012.
300 _aXI, 469 p. 118 illus., 30 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aInternal standards for quantitative LC-MS bioanalysis -- Method development, validation and sample analysis for regulated quantitative bioanalysis using LC-MS/MS -- Impact of sampling paper/cards on bioanalytical quantitation via dried blood spots by liquid chromatography - mass spectrometry -- Highly sensitive pharmaceutical and clinical analysis using selective solid-phase extraction coupled to microflow liquid chromatography and isotope-dilution mass spectrometry -- Pitfalls of LC-MS/MS in the clinical laboratory -- Therapeutic drug monitoring to support clinical pharmacogenomics -- Liquid chromatography - mass spectrometry for the determination of antidepressants and some of their major metabolites in human biological matrices -- The analysis of antipsychotic drugs in human biosamples by LC-MS -- Therapeutic drug monitoring of targeted anticancer therapy - tyrosine kinase inhibitors and selective oestrogen receptor modulators: a clinical pharmacology laboratory perspective -- Applications of mass spectrometry in analyses of steroid hormones -- Liquid chromatography - mass spectrometric analysis of tropane alkaloids in mammalian samples: techniques and applications -- Analysis of illicit drugs in human biological samples by LC-MSn -- Use of matrix assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) in the development of novel small molecule drugs -- A planar integrated micro mass spectrometer.
520 _a            High performance liquid chromatography – mass spectrometry (LC-MS) combines the separation power of liquid chromatography with the high sensitivity and selectivity of mass spectrometry. Therefore, LC-MS becomes the method of choice for drug bioanalysis in therapeutic drug monitoring, toxicology, and drug discovery and development. LC-MS in Drug Bioanalysis offers discussions on:             ● LC-MS/MS method development and validation in a regulated environment             ● Internal standard use in LC-MS/MS bioanalysis             ● Pitfalls of LC-MS/MS and how to overcome them             ● Dried blood spot sampling             ● Microflow LC-MS/MS             ● LC-MS/MS in therapeutic drug monitoring             ● Applications of LC-MS/MS in drug bioanalysis This book will aid readers to improve their skills in LC-MS/MS method development, validation, and applications in the analysis of drugs and their metabolites in complex biological matrices.  In addition, this book provides detailed information on the bioanalysis of antidepressants, antipsychotics, steroid hormones, anticancer agents, and drugs of abuse. Newer methodologies are discussed including the use of unique sample preparation techniques and the implementation of imaging mass spectrometry in the localization of drug and drug metabolites in tissues.
650 0 _aChemistry.
650 0 _aToxicology.
650 0 _aAnalytical biochemistry.
650 0 _aMass spectrometry.
650 0 _aChromatography.
650 1 4 _aChemistry.
650 2 4 _aMass Spectrometry.
650 2 4 _aAnalytical Chemistry.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aChromatography.
700 1 _aMadden, Timothy L.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461438274
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-3828-1
912 _aZDB-2-CMS
999 _c101450
_d101450