000 04487nam a22004815i 4500
001 978-1-4614-3667-6
003 DE-He213
005 20140220083248.0
007 cr nn 008mamaa
008 120605s2012 xxu| s |||| 0|eng d
020 _a9781461436676
_9978-1-4614-3667-6
024 7 _a10.1007/978-1-4614-3667-6
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8
_223
100 1 _aGaloyan, Armen A.
_eauthor.
245 1 0 _aBrain Immune System Signal Molecules in Protection from Aerobic and Anaerobic Infections
_h[electronic resource] /
_cby Armen A. Galoyan.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2012.
300 _aXV, 198 p. 80 illus., 44 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Neurobiology,
_x2190-5215 ;
_v6
505 0 _aThe Cytokine System -- The Discovery of the Brain Immunomodulalors -- Brain Neuroendocrine Immune System: Neurosecretion of Interleukins and New Cytokines by NSO and NPV of Hypothalamus -- Antibacterial and Antiviral Activity of Galarmin (PRP-1) and Some Immunological Mechanisms of its Action -- Treatment and Prophylaxis of Anthrax by Galarmin: Receptor Tyrosine Kinase is a Target of Galarmin -- Prophylaxis and Treatment of Methicillin-Resistant Staphylococcus Aureus (Mrsa) Infection by Galarmin and D-15 Galarmin in Vivo -- Treatment of Clostridium Perfringens-Induced Gas Gangrene by New Cytokines of Brain -- Investigation of Protective and Immunogenic Properties of Hypothalamic Proline Polypeptides Galarmin and Gx-NH2 Against Mycobacterium Tuberculosis -- Brain - Bone Marrow Neurohumoral Axis: Galarmin Controls Differentiation, Proliferation and Mobilization of Bone-Marrow Progenitor Cells -- Antioxidant-Antiradical and Electron Donating Functions of Galarmin and Gx-NH2 -- Discussion -- Summary.Galarmin and Gx-NH2 -- Discussion -- Summary.
520 _aDr. Galoyan is a pioneer of the specialized field of neuroimmunology. During his 45-year-long career, he has discovered a neuroendocrine immune system of the brain and identified a new type of brain cytokines: proline-rich polypeptides. The most important of these, PRP-1 (galarmin) has been shown to possess antibacterial properties and protect from certain neurotoxins. Proline-rich polypeptides—in particular (PRP-1) galarmin and its structural analogues—are, when isolated from the neurosecretory granules of neurohypophysis of humans and animals, a new type of hypothalamic peptides. They work against aerobic, anaerobic, gram-positive, and gram-negative microorganisms in vivo, and do not have etiotropic properties. They are unique and capable substitutes to antibiotics, and, moreover, may be effective against strains, such as MRSA, that develop resistance to antibiotics. Galarmin, a component of the brain neuroendocrine system produced by the neurosecretory cells of hypothalamus, possesses  immunomodulative, neuroprotective, antioxidant, antitumorigenic and hematopoietic properties. Moreover, galarmin and its structural analogues are powerful anti-inflammatory  compounds.  In addition to presenting a full overview of the neuroimmune system, it emphasizes the antibacterial, neuroprotective, and neuroregenerative properties of proline-rich polypeptides.  It investigates the mechanism of galarmin’s action during different infectious processes, where it targets such dangerous pathogens as  Bacillus anthracis, Clostridium perfringens, Mycobacterium tuberculosis, and Methycillin resistant Staphylococcus aureus.   This research is important from both a theoretical and clinical point of view, creating new prospects for the modern pharmaceutical industry and neuroendocrine, neuroimmunological sciences.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aNeurosciences.
650 0 _aNeurobiology.
650 1 4 _aBiomedicine.
650 2 4 _aNeurosciences.
650 2 4 _aNeurobiology.
650 2 4 _aImmunology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461436669
830 0 _aAdvances in Neurobiology,
_x2190-5215 ;
_v6
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-3667-6
912 _aZDB-2-SBL
999 _c101420
_d101420