000 02911nam a22004815i 4500
001 978-1-4614-3411-5
003 DE-He213
005 20140220083247.0
007 cr nn 008mamaa
008 120507s2012 xxu| s |||| 0|eng d
020 _a9781461434115
_9978-1-4614-3411-5
024 7 _a10.1007/978-1-4614-3411-5
_2doi
050 4 _aQH301-705
072 7 _aPSA
_2bicssc
072 7 _aSCI086000
_2bisacsh
072 7 _aSCI064000
_2bisacsh
082 0 4 _a570
_223
100 1 _aWellstead, Peter.
_eeditor.
245 1 0 _aSystems Biology of Parkinson's Disease
_h[electronic resource] /
_cedited by Peter Wellstead, Mathieu Cloutier.
264 1 _aNew York, NY :
_bSpringer New York,
_c2012.
300 _aXVI, 176p. 42 illus., 21 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aImaging of dopaminergic neurons and the implications for Parkinson’s disease -- Modelling and simulation of brain energy metabolism: energy and Parkinson's disease -- Systems Biology of Aging: Opportunities for Parkinson’s Disease -- Mitochondrion- and Endoplasmic Reticulum-Induced SK Channel Dysregulation as a Potential Origin of the Selective Neurodegeneration in Parkinson’s Disease -- Energetics of Ion Transport in Dopaminergic Substantia nigra Neurons: ion exchange dynamics at the pacemaking membrane -- Real-time In Vivo Sensing of Neurochemicals -- Modeling protein and oxidative metabolism in Parkinson's disease -- Mathematical Models of Dopamine Metabolism in Parkinson’s Disease -- Index.
520 _aThis text is the first to present a study of Parkinson’s disease from a Systems Biology perspective. By placing the condition at centre stage, the authors have been able to provide a wide ranging modelling and systems analysis that is focussed on a multi-facetted and highly complex condition. The book comprises a specially selected set of eight studies of important aspects of PD, covering all relevant scales of space and time. These are used to show how innovative sensing techniques, mathematical modelling, model analysis and computational simulation can throw new light on the dynamics of disease mechanisms that drive this important form of neurodegeneration.
650 0 _aLife sciences.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aBiological models.
650 1 4 _aLife Sciences.
650 2 4 _aSystems Biology.
650 2 4 _aNeurosciences.
650 2 4 _aBiomedicine general.
700 1 _aCloutier, Mathieu.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461434108
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-3411-5
912 _aZDB-2-SBL
999 _c101363
_d101363