000 04284nam a22005055i 4500
001 978-1-4614-3345-3
003 DE-He213
005 20140220083247.0
007 cr nn 008mamaa
008 120613s2012 xxu| s |||| 0|eng d
020 _a9781461433453
_9978-1-4614-3345-3
024 7 _a10.1007/978-1-4614-3345-3
_2doi
050 4 _aQR46
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9041
_223
100 1 _aMinarovits, Janos.
_eeditor.
245 1 0 _aPatho-Epigenetics of Disease
_h[electronic resource] /
_cedited by Janos Minarovits, Hans Helmut Niller.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2012.
300 _aXIII, 465 p. 25 illus., 14 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aEpigenetic regulatory mechanisms -- Role of DNMT3B Mutations in the Pathogenesis of ICF Syndrome -- Dysfunction of the Methyl-Cpg Binding Protein Mecp2 in Rett Syndrome -- Epigenetic Alterations in Glioblastoma Multiforme -- Aberrant Epigenetic Regulation in Breast Cancer -- The Impact of Epigenetic Alterations on Diagnosis, Prediction and Therapy of Prostate Cancer -- Epigenetic Reprogramming in Lung Carcinomas -- Epigenetic changes in virus associated neoplasms -- Genetic and Epigenetic Determinants of Aggression -- Co-Regulation and Epigenetic Dysregulation in Schizophrenia and Bipolar Disorder -- Disruption of Epigenetic Mechanisms in Autoimmune Syndromes -- Imprinting Disorders -- Epigenetics of cardiovascular diseases -- Microbe-induced epigenetic alterations.
520 _aIn multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMicrobiology.
650 0 _aMedical virology.
650 0 _aEmerging infectious diseases.
650 1 4 _aBiomedicine.
650 2 4 _aMedical Microbiology.
650 2 4 _aMedicine/Public Health, general.
650 2 4 _aVirology.
650 2 4 _aInfectious Diseases.
650 2 4 _aImmunology.
700 1 _aNiller, Hans Helmut.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461433446
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-3345-3
912 _aZDB-2-SBL
999 _c101347
_d101347