000 04250nam a22004695i 4500
001 978-1-4614-2383-6
003 DE-He213
005 20140220083246.0
007 cr nn 008mamaa
008 120322s2012 xxu| s |||| 0|eng d
020 _a9781461423836
_9978-1-4614-2383-6
024 7 _a10.1007/978-1-4614-2383-6
_2doi
050 4 _aQP356.3
072 7 _aMJN
_2bicssc
072 7 _aMED057000
_2bisacsh
082 0 4 _a612.8042
_223
100 1 _aCeccatelli, Sandra.
_eeditor.
245 1 0 _aMethylmercury and Neurotoxicity
_h[electronic resource] /
_cedited by Sandra Ceccatelli, Michael Aschner.
264 1 _aBoston, MA :
_bSpringer US,
_c2012.
300 _aXI, 373p. 59 illus., 15 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Neurotoxicity ;
_v2
505 0 _aEpidemiological Update on Methylmercury and Minamata Disease -- Epidemiological Evidence On Methylmercury Neurotoxicity -- The Impact of Prenatal Exposure to Methylmercury and Maternal Nutritional Status on Child Development: Findings from the Seychelles Child Development Study -- Methylmercury and Fish Nutrients in Experimental Models -- Mercury-Dependent Inhibition of Selenoenzymes and Mercury Toxicity -- Redox State in Mediating Methylmercury Neurotoxicity -- The Role of Thyroid Modulation by Methylmercury in Developmental Neurotoxicity -- Effects of Developmental Methylmercury Exposure on Nervous System Function in Monkeys -- Behavioural Effects of Exposure to Methylmercury During Early Development -- Epigenetics of Environmental Contaminants -- Methylmercury Neurotoxicity: a Synopsis of in vitro Effects -- Effects of Methylmercury on Cellular Signal Transduction Systems -- Methylmercury neurotoxicity: Why are some cells are more vulnerable than others? -- In vitro Models for Methylmercury Neurotoxicity: Effects on Glutamatergic Cerebellar Granule Neurons -- Methylmercury and Glia Cells -- Methylmercury and Neural Stem Cells -- Contributions of the Drosophila Model to Understanding Methylmercury Effects on Development -- Caenorhabditis elegans as a Predictive Model for Methylmecury-Induced Neurotoxicity -- Zebrafish as a Model for Methylmercury Neurotoxicity -- Piscivorous Mammalian Wildlife as Sentinels of Methylmercury Exposure and Neurotoxicity in Humans.
520 _aMercury (Hg) is a global pollutant that knows no environmental boundaries. Even the most stringent control of anthropogenic Hg sources will not eliminate exposure given its ubiquitous presence. Exposure to Hg occurs primarily via the food chain due to MeHg’s accumulation in fish. Latest US statistics indicate that 46 States have fish consumption advisories. In addition, Hg is a common pollutant in hazardous waste sites, with an estimated 3-4 million children living within one mile of at least one of the 1,300+ active hazardous waste sites in the US. The effects on intellectual function in children prenatally exposed to MeHg via maternal fish consumption have been the subject of two on-going major, prospective, longitudinal studies in the Seychelles and the Faroe Islands. It is important to recognize that the risk for MeHg exposure is not limited only to islanders with high fish consumption. This book will provide state-of-the-art information to the graduate student training in toxicology, risk assessors, researchers and medical providers at large. It is aimed to bring the reader up to date on contemporary issues associated with exposure to methylmercury, from its effects on stem cells and neurons to population studies.
650 0 _aMedicine.
650 0 _aNeurochemistry.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aNeurochemistry.
650 2 4 _aPharmacology/Toxicology.
700 1 _aAschner, Michael.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461423829
830 0 _aCurrent Topics in Neurotoxicity ;
_v2
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-2383-6
912 _aZDB-2-SBL
999 _c101273
_d101273