000 03912nam a22004935i 4500
001 978-1-4614-2146-7
003 DE-He213
005 20140220083245.0
007 cr nn 008mamaa
008 120209s2012 xxu| s |||| 0|eng d
020 _a9781461421467
_9978-1-4614-2146-7
024 7 _a10.1007/978-1-4614-2146-7
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aPHVD
_2bicssc
072 7 _aSCI009000
_2bisacsh
082 0 4 _a571.4
_223
100 1 _aDokholyan, Nikolay V.
_eeditor.
245 1 0 _aComputational Modeling of Biological Systems
_h[electronic resource] :
_bFrom Molecules to Pathways /
_cedited by Nikolay V Dokholyan.
264 1 _aBoston, MA :
_bSpringer US,
_c2012.
300 _aVI, 364p. 98 illus., 77 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiological and Medical Physics, Biomedical Engineering,
_x1618-7210
505 0 _aPart I Molecular Modeling -- Introduction to Molecular Dynamics: Theory and Applications in Biomolecular Modeling -- The Many Faces of Structure-Based Potentials: From Protein Folding Landscapes to Structural Characterization of Complex Biomolecules -- Discrete Molecular Dynamics Simulation of Biomolecules -- Small Molecule Docking from Theoretical Structural Models -- Homology Modeling: Generating Structural Models to Understand Protein Function and Mechanism -- Quantum Mechanical Insights into Biological Processes at the Electronic Level -- Part II Modeling Macromolecular Assemblies -- Multiscale Modeling of Virus Structure, Assembly and Dynamics -- Mechanisms and Kinetics of Amyloid Aggregation Investigated by a Phenomenological Coarse-Grained Model -- The Structure of Intrinsically Disordered Peptides Implicated in Amyloid Diseases: Insights from Fully Atomistic Simulations -- Part III Modeling Cells and Cellular Pathways -- Computer Simulations of Mechano-Chemical Networks: Choreographing Actin Dynamics in Cell Motility -- Computational and Modeling Strategies for Cell Motility -- Theoretical Analysis of Molecular Transport Across Membrane Channels and Nanopores -- Part IV Modeling Evolution -- Modeling Protein Evolution -- Modeling Structural and Genomic Constraints in the Evolution of Proteins -- Modeling Proteins at the Interface of Structure, Evolution, and Population Genetics.
520 _aComputational modeling is emerging as a powerful new approach for studying and manipulating biological systems. Many diverse methods have been developed to model, visualize, and rationally alter these systems at various length scales, from atomic resolution to the level of cellular pathways. Processes taking place at larger time and length scales, such as molecular evolution, have also greatly benefited from new breeds of computational approaches. Computational Modeling of Biological Systems: From Molecules to Pathways provides an overview of established computational methods for the modeling of biologically and medically relevant systems. It is suitable for researchers and professionals working in the fields of biophysics, computational biology, systems biology, and molecular medicine.
650 0 _aPhysics.
650 0 _aMedicine.
650 0 _aBioinformatics.
650 1 4 _aPhysics.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aMolecular Medicine.
650 2 4 _aMathematical and Computational Biology.
650 2 4 _aComputational Biology/Bioinformatics.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461421450
830 0 _aBiological and Medical Physics, Biomedical Engineering,
_x1618-7210
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-2146-7
912 _aZDB-2-PHA
999 _c101213
_d101213