000 03477nam a22004815i 4500
001 978-1-4614-1689-0
003 DE-He213
005 20140220083243.0
007 cr nn 008mamaa
008 120614s2012 xxu| s |||| 0|eng d
020 _a9781461416890
_9978-1-4614-1689-0
024 7 _a10.1007/978-1-4614-1689-0
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
100 1 _aSuhre, Karsten.
_eeditor.
245 1 0 _aGenetics Meets Metabolomics
_h[electronic resource] :
_bfrom Experiment to Systems Biology /
_cedited by Karsten Suhre.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2012.
300 _aXX, 318 p. 77 illus., 45 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction -- Pre-conditions for high quality biobanking in large human epidemiological cohorts for metabolomics and other -omics studies -- Assay Tools for Metabolomics -- Statistical methods in genetic and molecular epidemiology and their application in studies with metabolic phenotypes -- Ultrahigh resolution mass spectrometry based non-targeted microbial metabolomics -- etabolomic systems biology of protozoan parasites -- Mouse genetics and metabolic mouse phenotyping -- Metabolomics in animal breeding -- Metabolomics applications in human nutrition -- Metabolomics for the individualized therapy of androgen deficiency syndrome in male adults -- Systems biology resources arising from the human metabolome project -- Understanding cancer metabolism through global metabolomics -- Genetic and metabolic determinants of fatty acid chain length and desaturation, their incorporation into lipid classes and their effects on risk of vascular and metabolic disease -- Mapping metabolomic quantitative trait loci (mQTL) – A link between metabolome-wide association studies and systems biology -- Metabolic traits as intermediate phenotype -- Genome-wide association studies with metabolomics -- Systems biology meets metabolism -- Index.
520 _aUnlike previous books published on metabolomics, this book switches the focus from experimental questions and technical challenges, to the application of metabolomics with an emphasis on the underlying genetics. The chapters provide a thorough basis for the understanding of the underlying experimental techniques, concepts and potential biomedical applications of this exciting field. The interdisciplinary approach of this book addresses a wide readership, and contains educational aids for anyone not familiar with a particular area of metabolomics. The area of research where genetics and metabolomics meet is likely to represent a field where systems biology shall prosper highly in the years to come.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aBiological models.
650 0 _aMetabolism.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aMetabolomics.
650 2 4 _aSystems Biology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461416883
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-1689-0
912 _aZDB-2-SBL
999 _c101118
_d101118