000			04506nam a22005055i 4500
001			978-1-4614-1542-8
003			DE-He213
005			20140220083243.0
007			cr nn 008mamaa
008			111205s2012 xxu| s |||| 0|eng d
020			_a9781461415428 _9978-1-4614-1542-8
024	7		_a10.1007/978-1-4614-1542-8 _2doi
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aMED057000 _2bisacsh
082	0	4	_a612.8 _223
100	1		_aAntkiewicz-Michaluk, Lucyna. _eeditor.
245	1	0	_aIsoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants _h[electronic resource] : _bNew Vistas In Parkinson's Disease Therapy / _cedited by Lucyna Antkiewicz-Michaluk, Hans Rommelspacher.
250			_a1.
264		1	_aBoston, MA : _bSpringer US, _c2012.
300			_aX, 177p. 34 illus., 3 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Topics in Neurotoxicity ; _v1
505	0		_aTwo faces of 1,2,3,4-tetrahydroisoquinoline mode of action in the mammalian brain: is it an endogenous neurotoxin or a neuromodulator? -- Isoquinolines as a neurotoxins: action and molecular mechanism -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline – a potent neuroprotecting agent -- 1-Methyl-1,2,3,4-tetrahydroisoquinoline and addiction: experimental studies -- Beta-carbolines as neurotoxins -- Neuroprotective β-carbolines: occurrence, formation and biodegradation -- Beta-carbolines and neuroprotection: inhibition of monoamine oxidase -- Beta-carbolines increase the efficiency of the respiratory chain in mitochondria -- Antioxidant properties of β-carbolines -- Restoration of neuronal functions in damaged dopamine neurons: in vitro and in vivo studies -- Prospects for new treatment options in neurodegenerative diseases.
520			_aThis book summarizes, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.  Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease. The specific topic, Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New Perspectives In Parkinson's Disease Therapy, was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson's disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): BCs and TIQs. These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively, and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances.
650		0	_aMedicine.
650		0	_aNeurosciences.
650		0	_aNeurochemistry.
650		0	_aPharmacy.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
650	2	4	_aNeurochemistry.
650	2	4	_aPharmacy.
700	1		_aRommelspacher, Hans. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461415411
830		0	_aCurrent Topics in Neurotoxicity ; _v1
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-1542-8
912			_aZDB-2-SBL
999			_c101090 _d101090