000 03109nam a22004815i 4500
001 978-1-4614-1400-1
003 DE-He213
005 20140220083242.0
007 cr nn 008mamaa
008 111217s2012 xxu| s |||| 0|eng d
020 _a9781461414001
_9978-1-4614-1400-1
024 7 _a10.1007/978-1-4614-1400-1
_2doi
050 4 _aQR46
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9041
_223
100 1 _aDougherty, Thomas J.
_eeditor.
245 1 0 _aAntibiotic Discovery and Development
_h[electronic resource] /
_cedited by Thomas J. Dougherty, Michael J. Pucci.
264 1 _aBoston, MA :
_bSpringer US,
_c2012.
300 _aXVII, 1127p. 211 illus., 80 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroductory History of Antimicrobial Drugs -- Marketed Major Classes of Compounds -- The Rise of Antibiotic Resistance/Resistance Mechanisms to Major Classes -- Clinical Issues of Resistance: “Worst Offenders” List of Problematic Microbes -- Antibiotic Discovery -- Antibiotic Drug Development -- The Economics and Incentives of Antibiotic Drug Discovery.
520 _aThis volume covers major aspects of the antibiotic discovery and development process. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the historical perspectives of antibiotic discovery, the need for new antibiotic compounds,strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Significant attention is given to existing antibiotics, their resistance mechanisms, and new efforts to overcome resistance within these classes.  Beyond discovery, the book covers the studies to prepare for IND submission and NDA filings. This book walks the reader through virtually all aspects of antibiotic discovery, which has never been done before in a single reference. With the alarming rise in antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the book is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
650 0 _aMedicine.
650 0 _aMicrobiology.
650 0 _aToxicology.
650 0 _aChemistry, Physical organic.
650 1 4 _aBiomedicine.
650 2 4 _aMedical Microbiology.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aPhysical Chemistry.
650 2 4 _aMolecular Medicine.
700 1 _aPucci, Michael J.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461413998
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-1400-1
912 _aZDB-2-SBL
999 _c101059
_d101059