| 000 | 04613nam a22004335i 4500 | ||
|---|---|---|---|
| 001 | 978-1-4614-1192-5 | ||
| 003 | DE-He213 | ||
| 005 | 20140220083241.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 111116s2012 xxu| s |||| 0|eng d | ||
| 020 |
_a9781461411925 _9978-1-4614-1192-5 |
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| 024 | 7 |
_a10.1007/978-1-4614-1192-5 _2doi |
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| 050 | 4 | _aRC841-858.P35 | |
| 072 | 7 |
_aMJJ _2bicssc |
|
| 072 | 7 |
_aMED031000 _2bisacsh |
|
| 082 | 0 | 4 |
_a616.36 _223 |
| 100 | 1 |
_aShiffman, Mitchell L. _eeditor. |
|
| 245 | 1 | 0 |
_aChronic Hepatitis C Virus _h[electronic resource] : _bAdvances in Treatment, Promise for the Future / _cedited by Mitchell L. Shiffman. |
| 264 | 1 |
_aNew York, NY : _bSpringer New York, _c2012. |
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| 300 |
_aXVI, 332 p. 53 illus., 33 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 505 | 0 | _aEpidemiology of Chronic HCV -- Acute HCV.-Assessing the Progression of Chronic HCV to Cirrhosis.- Chronic HCV and Steatosis -- Chronic HCV and Hepatocellular Carcinoma.-Extrahepatic Manifestations of Chronic HCV.-Chronic HCV and HIV Co-infection -- Chronic HCV in Patients with Renal Disease.-Does Treatment Alter the Natural History of Chronic HCV.-Treatment with Interferon and Ribavirin -- Immune Modulators and Other Agents.-Measuring HCV RNA and Assessing Virologic Response -- Response Guided Therapy.-Managing the Side Effects of Therapy.-The Genetics of Virologic Response -- Maintenance Therapy with Peginterferon.-Anti-viral Targets in HCV/-Mutations and the Development of Anti-viral Resistance -- Peginterferon, Ribavirin and Anti-viral Triple Therapy.-Treating Chronic HCV without Interferon and/or Ribavirin -- Maintenance Therapy with Oral Anti-viral Agents -- Natural History of Chronic HCV after Liver Transplantation.-Use of HCV Positive Organs in Patients with and without Chronic HCV -- Treating HCV Prior to Liver Transplantation -- Treating HCV after Liver Transplantation. . | |
| 520 | _aChronic Hepatitis C Virus: Advances in Treatment, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aGastroenterology. | |
| 650 | 0 | _aClinical medicine. | |
| 650 | 1 | 4 | _aMedicine & Public Health. |
| 650 | 2 | 4 | _aHepatology. |
| 650 | 2 | 4 | _aGastroenterology. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781461411918 |
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-1192-5 |
| 912 | _aZDB-2-SME | ||
| 999 |
_c101011 _d101011 |
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