000 03285nam a22004935i 4500
001 978-1-4614-1049-2
003 DE-He213
005 20140220083241.0
007 cr nn 008mamaa
008 111115s2012 xxu| s |||| 0|eng d
020 _a9781461410492
_9978-1-4614-1049-2
024 7 _a10.1007/978-1-4614-1049-2
_2doi
050 4 _aQP34-38
072 7 _aMFG
_2bicssc
072 7 _aMED075000
_2bisacsh
082 0 4 _a612
_223
100 1 _aChen, Chang-Hwei.
_eauthor.
245 1 0 _aActivation and Detoxification Enzymes
_h[electronic resource] :
_bFunctions and Implications /
_cby Chang-Hwei Chen.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2012.
300 _aXIV, 182 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aOverview -- Lipophilic Foreign Compounds -- Metabolic Conversion of Lipophilic Compounds -- Phase I Enzymes -- Phase II Enzymes -- Reactive Intermediate Formation -- Biomedical and Biochemical Effects -- Genetic Variations in Metabolizing Enzymes -- Inducibility of Metabolizing Enzymes -- Induction and Inhibition Compounds -- Diets Rich in Enzyme Modulators -- Induction of Enzymes for Health Benefits -- Sources of Foreign Compounds -- Catalytic Reactions of Phase I Enzymes -- Catalytic Reactions of Phase II Enzymes -- Diversified Classes of Enzyme Modulators -- Conclusion -- Index.
520 _aThere are many advances that have been made in the past decades towards the understanding of functions and implications of activation enzymes and detoxification enzymes. An organized, concise overview is needed for the readers who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology and chemistry. This book is intended to serve this purpose as an introduction to the subject. Furthermore, major topics in the book, excluding catalytic reactions and structural properties, may have interest to other readers who have knowledge of basic sciences and understanding enzyme related information. The book discusses subjects associated with foreign compound metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, phase I and phase II enzymes, catalytic properties, reactive intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary related enzyme modulators, and structural characteristics of enzyme inducers. 
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aToxicology.
650 0 _aEnzymes.
650 0 _aMetabolism.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Physiology.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aHealth Promotion and Disease Prevention.
650 2 4 _aEnzymology.
650 2 4 _aMetabolomics.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461410485
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-1049-2
912 _aZDB-2-SBL
999 _c100979
_d100979