000			03331nam a22004935i 4500
001			978-1-4614-1001-0
003			DE-He213
005			20140220083241.0
007			cr nn 008mamaa
008			111101s2012 xxu| s |||| 0|eng d
020			_a9781461410010 _9978-1-4614-1001-0
024	7		_a10.1007/978-1-4614-1001-0 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aMercier, Isabelle. _eeditor.
245	1	0	_aCaveolins in Cancer Pathogenesis, Prevention and Therapy _h[electronic resource] / _cedited by Isabelle Mercier, Jean-François Jasmin, Michael P. Lisanti.
250			_a1.
264		1	_aNew York, NY : _bSpringer New York, _c2012.
300			_aXII, 124 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCurrent Cancer Research
505	0		_aPreface -- Local and Distant Effects of Caveolin-1 on Prostate Cancer Progression -- Caveolin-1 in Colon Cancer: the Flexible Connection to Wnt Signaling -- Caveolin-1 and Pancreatic Ductal Adenocarcinoma -- Caveolin-1 in Brain Tumors -- The Role of Caveolin-1 in Skin Cancer -- Caveolins and Tumor Angiogenesis -- Caveolin-1 and Breast Cancer -- Caveolin-1 and Cancer-Associated Stromal Fibroblasts -- Index .
520			_aFor more than a decade, caveolin proteins have attracted a lot of attention in the field of cancer research. Additional roles besides maintaining the structural integrity of caveolae (meaning “little caves” in latin) have been attributed to these complex proteins. In fact, they have emerged as important regulators of cell signaling, proliferation, invasion and angiogenesis. The current book focuses on caveolin-1, the best-studied and well- characterized of all three caveolin family members (caveolin-1, -2 and -3). As such, the current chapters illustrate the roles of caveolin-1 in breast, prostate, skin, colon, brain and pancreatic cancers, and highlight its specific contribution to tumor growth through epithelial and stromal interactions, as well as its involvement in angiogenesis. This book summarizes the existing literature and provides interesting new perspectives on future advancement and therapeutic possibilities involving caveolins in cancer. This work brings together highly respected and experienced scientists in the field of caveolins who wrote informative chapters on the role of caveolin-1 in cancer in a format that conveys its role as both a tumor suppressor and tumor promoter. We invite you to read, enjoy and be part of these new promising discoveries that are rapidly advancing the field of cancer research.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aToxicology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aPharmacology/Toxicology.
700	1		_aJasmin, Jean-François. _eeditor.
700	1		_aLisanti, Michael P. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461410003
830		0	_aCurrent Cancer Research
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-1001-0
912			_aZDB-2-SME
999			_c100968 _d100968