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001 978-1-4614-0980-9
003 DE-He213
005 20140220083241.0
007 cr nn 008mamaa
008 120201s2012 xxu| s |||| 0|eng d
020 _a9781461409809
_9978-1-4614-0980-9
024 7 _a10.1007/978-1-4614-0980-9
_2doi
050 4 _aQR355-502
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9101
_223
100 1 _aRossmann, Michael G.
_eeditor.
245 1 0 _aViral Molecular Machines
_h[electronic resource] /
_cedited by Michael G. Rossmann, Venigalla B. Rao.
264 1 _aBoston, MA :
_bSpringer US,
_c2012.
300 _aXIV, 687p. 221 illus., 192 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v726
505 0 _aViruses: Sophistiated Biological Machines -- F1-Atpase: A Prototypical Molecular Motor -- Reconstructing Virus Structures From Nanometer To Near-Atomic Resolutions With Cryo-Electron Microscropy And Tomography -- Principles Of Virus Structural Organization -- Viral Entry Machines -- Genome Replication Machines -- Capsid Assembly And Maturation -- Genome Packaging Machines.
520 _aA biological organism can be viewed as a collection of molecular machines well integrated to function as a self-replicating unit. One of the principal goals in biology is to be able to fully understand the mechanisms of an organism in atomic detail. Viruses offer the best opportunities to achieve this goal. Written by leaders in the respective fields, this book examines a variety of viral molecular machines, using the best examples from bacteriophages and animal viruses, many causing infectious diseases of public health importance. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, assembly of structural components, genome packaging and maturation into an infectious virion. The book conveys the state of the art knowledge of the topic generated by combining X-ray crystallography, high resolution electron microscopy, molecular genetics, biochemistry, and single molecule biophysics. Viral Molecular Machines is not only a “must-have” book for virologists but it will also be broadly useful for molecular biologists in academia and industry as well as an educational tool for teaching graduate and upper level undergraduate students.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMedical virology.
650 0 _aEmerging infectious diseases.
650 0 _aMicrobiology.
650 1 4 _aBiomedicine.
650 2 4 _aVirology.
650 2 4 _aMicrobiology.
650 2 4 _aInfectious Diseases.
650 2 4 _aImmunology.
700 1 _aRao, Venigalla B.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461409793
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v726
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-0980-9
912 _aZDB-2-SBL
999 _c100966
_d100966