000 03099nam a22004455i 4500
001 978-1-4614-0662-4
003 DE-He213
005 20140220083239.0
007 cr nn 008mamaa
008 111004s2012 xxu| s |||| 0|eng d
020 _a9781461406624
_9978-1-4614-0662-4
024 7 _a10.1007/978-1-4614-0662-4
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aLawrence, Toby.
_eeditor.
245 1 0 _aTumour-Associated Macrophages
_h[electronic resource] /
_cedited by Toby Lawrence, Thorsten Hagemann.
264 1 _aNew York, NY :
_bSpringer New York,
_c2012.
300 _aXI, 187 p. 15 illus., 10 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Macrophage Phenotype in Tumors -- Role of Tumour-Associated Macrophages in the Regulation of Tumour Angiogenesis -- The Role of Tumor-Associated Macrophages in Malignant Invasion -- Tumor-Induced Immune Suppression by Myeloid Cells -- TAM: A Moving Clinical Target -- Arginine Metanolism and Tumour Associated Macrophages -- Indoleamine 2,3-dioxygenaseAmino acid metabolism and tumor-associated macrophages: regulation in cancer-associated inflammation and immune escape -- Vascular Endothelial Growth Factor and Tumor-associated macrophages -- TLR Signaling and Tumor-associated Macrophages -- SHIP and Tumor-Associated Macrophages -- NF-KappaB-Mediated Regulation of Tumor-Associated Macrophages: Mechanisms and Signifance -- Role of hypoxia-inducible transcription factors HIF-a for TAM function -- Index.        .
520 _aMacrophages are tissue resident phagocytes that have important roles in development and immunity. The observation that cancers become infiltrated by large numbers of macrophages was first made by Virchow in 1863, clinical and experimental studies suggest tumor-associated macrophages (TAM) are critical to promote carcinogenesis and tumor-progression, however to this day it still isn’t clear what regulates the recruitment of macrophages in tumors and what drives their pro-tumor functions. This volume will provide an overview of current research on the form and function of TAM, highlighting both the mechanistic roles they play in carcinogenesis and tumor progression as well as the molecular mechanisms that control their phenotype and function, and the final chapter addresses the issue of TAM as a potential target in cancer therapy.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
700 1 _aHagemann, Thorsten.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461406617
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-0662-4
912 _aZDB-2-SBL
999 _c100902
_d100902