000 04477nam a22004575i 4500
001 978-1-4419-9914-6
003 DE-He213
005 20140220083234.0
007 cr nn 008mamaa
008 111129s2012 xxu| s |||| 0|eng d
020 _a9781441999146
_9978-1-4419-9914-6
024 7 _a10.1007/978-1-4419-9914-6
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aWang, Rongfu.
_eeditor.
245 1 0 _aInnate Immune Regulation and Cancer Immunotherapy
_h[electronic resource] /
_cedited by Rongfu Wang.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2012.
300 _aX, 478 p. 39 illus., 32 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction -- The role of NKT cells in the immune regulation of neoplastic disease.- γδ T Cells in Cancer -- Toll-like receptors and their regulatory mechanisms -- Cytoplasmic sensing of viral double-stranded RNA and activation of innate immunity by RIG-I-Like Receptors -- Innate immune signaling and negative regulators in cancer -- Dendritic Cell Subsets and Immune Regulation -- Human Dendritic Cells in Cancer -- Regulatory T cells in cancer -- Relationship between Th17 and regulatory T cells in the tumor environment -- Mechanisms and control of regulatory T cells in cancer -- Myeloid Derived Suppressor Cells in Cancer -- Myeloid Derived Suppressor Cells and Treg cells in Tumor Microenvironment -- Cell Surface Co-Signaling Molecules in the Control of Innate and Adaptive Cancer Immunity -- Negative regulators of NF-κB activation and type I interferon pathways -- Role of TGF-β in immune suppression and inflammation -- Indoleamine 2,3-dioxygenase and tumor-induced immune suppression -- Myeloid-Derived Suppressor Cells in Cancer:  Mechanisms and Therapeutic Perspectives -- Human tumor antigens recognized by T cells and their implications for cancer immunotherapy -- Cancer/testis (CT) Antigens: Potential Targets for Immunotherapy -- Tumor antigens and Immune Regulation in Cancer Immunotherapy -- Immunotherapy of Cancer -- Current Progress in Adoptive T-Cell Therapy of Lymphoma -- Adoptive Immunotherapy of Melanoma -- Index.
520 _aThere has been major growth in understanding innate immune signaling, inflammation, immune suppression and cancer immunotherapy. Innate immune regulation and cancer immunotherapy highlights emerging research about the underlying mechanisms of innate immunity and signaling regulation, inflammation and immune suppression that promote or inhibit cancer development and progression, and offers novel ideas and strategies to develop therapeutic cancer drugs or cell therapy by manipulating or blocking these negative signaling pathways and generating potent antitumor immunity.  Recent studies have identified key innate immune receptors or sensors, novel signaling molecules and immune regulatory molecules that control immune responses, inflammation and immune suppression in cancer and other diseases. Major progresses in understanding of tumor antigens, immune suppressive molecules and cell population and novel vaccine strategies bring therapeutic cancer vaccines and drugs in realty.  With chapters written by internationally recognized contributors, this book provides essential introduction and guide for immunologists, basic, translational and clinical cancer researchers. Features of this book: Offers the most recent development from basic science to clinical application of cancer immunotherapy, thus serving useful guide for immunologists, and cancer researcher and oncologists. Identify key immune signaling molecules and cell populations that dampen immune responses against cancer, thus providing novel strategies to develop therapeutic cancer vaccines and drugs.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aImmunology.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aImmunology.
650 2 4 _aPharmacology/Toxicology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441999139
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-9914-6
912 _aZDB-2-SBL
999 _c100606
_d100606