000			03861nam a22005175i 4500
001			978-0-85729-701-3
003			DE-He213
005			20140220083228.0
007			cr nn 008mamaa
008			111114s2012 xxk| s |||| 0|eng d
020			_a9780857297013 _9978-0-85729-701-3
024	7		_a10.1007/978-0-85729-701-3 _2doi
050		4	_aRC346-429.2
072		7	_aMJN _2bicssc
072		7	_aMED056000 _2bisacsh
082	0	4	_a616.8 _223
100	1		_aReeve, Amy Katherine. _eeditor.
245	1	0	_aMitochondrial Dysfunction in Neurodegenerative Disorders _h[electronic resource] / _cedited by Amy Katherine Reeve, Kim Jennifer Krishnan, Michael R. Duchen, Doug M Turnbull.
264		1	_aLondon : _bSpringer London : _bImprint: Springer, _c2012.
300			_aXXI, 242p. 20 illus., 12 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aAn Introduction to Mitochondria -- Neurodegeneration in Primary Mitochondrial Disorders -- Mutations in Nuclear Genes that Affect Mitochondrial Function in Parkinson’s Disease -- Common mtDNA Polymorphisms and Neurodegenerative Disorders -- MtDNA Mutations in Brain Ageing and Neurodegeneration -- Mitochondrial Dysfunction in Neurodegenerative Disease; Protein Aggregation, Autophagy and Oxidative Stress -- Mitochondria, Sodium and Calcium in Neuronal Dysfunction -- Mitochondrial Membrane Potential and Dynamics -- Dysfunction of the Ubiquitin/Proteasome System and Mitochondria in Neurodegenerative Disease -- Neuronal Mitochondrial Transport and Dysfunction -- Mitochondrial Changes Associated With Demyelination: Consequences for Axonal Integrity -- Modelling Mitochondrial Dysfunction in Neurodegenerative Disease -- Could Understanding the Role Of Mitochondria in Neurodegeneration Lead to Treatment?.
520			_aAs age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration.   Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets.   Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.
650		0	_aMedicine.
650		0	_aNeurosciences.
650		0	_aInternal medicine.
650		0	_aBiochemistry.
650		0	_aNeurology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aNeurology.
650	2	4	_aMedical Biochemistry.
650	2	4	_aNeurosciences.
650	2	4	_aInternal Medicine.
700	1		_aKrishnan, Kim Jennifer. _eeditor.
700	1		_aDuchen, Michael R. _eeditor.
700	1		_aTurnbull, Doug M. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780857297006
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-85729-701-3
912			_aZDB-2-SME
999			_c100270 _d100270