000 03758nam a22004815i 4500
001 978-94-007-7835-1
003 DE-He213
005 20140220082945.0
007 cr nn 008mamaa
008 131202s2013 ne | s |||| 0|eng d
020 _a9789400778351
_9978-94-007-7835-1
024 7 _a10.1007/978-94-007-7835-1
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aMalek, Anastasia.
_eeditor.
245 1 0 _aExperimental Metastasis: Modeling and Analysis
_h[electronic resource] /
_cedited by Anastasia Malek.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aVIII, 210 p. 71 illus., 32 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Introduction -- Head and neck cancer -- Breast cancer invasion and metastasis -- Mouse models of pancreatic cancer -- Brain Metastasis -- Lung metastasis -- Liver Metastases -- Malignant pleural effusion -- Mathematic modeling of metastatic process. Index.
520 _aMetastatic dissemination remains a main cause for cancer related deaths. Investigation of the molecular mechanisms of the metastatic process presents an important area of cancer research and may provide clinical oncologists with new methods to prevent and manage cancer dissemination. Availability of adequate experimental models is an essential requirement of the productive investigation. Over the many years of cancer research, plenty of model systems (in vitro and in vivo) were created to reproduce certain steps or to estimate certain aspects of metastatic process. Currently right selection and correct application of the experimental models as well as analytic technique may present a challenge. This book provide with guideline information about experimental modelling and analysis of the metastatic process. The structure of the book reflects clinical aspects: pathway and area of the metastatic dissemination. Thus, first part of book is devoted to local, mainly via lymph system, spread of head and neck, breast and pancreatic cancers. Second part is about distant, via blood stream, dissemination into brain and lung (most often sites of metastatic lesion regardless the primary tumour issue). Third part includes chapter describing methods of modelling and study specific metastatic pathways: via portal vein system and through serous cavities. Any chapter is introduced by short review of clinical/biological aspects of the specific metastatic process, provides with description of relevant laboratory techniques, supplemented with representative illustrations and extended references list. Theoretic aspects of cancer dissemination and mathematic approaches to model metastatic spread of tumour are reviewed in the last chapter. Chapters of the book are written by leading specialists in certain areas of metastatic cancer research, therefore the book presents a comprehensive guide for researchers and may be helpful for clinical oncologists.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aMedical laboratories.
650 0 _aCell culture.
650 0 _aLaboratory animals.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aLaboratory Medicine.
650 2 4 _aAnimal Models.
650 2 4 _aCell Culture.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400778344
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-7835-1
912 _aZDB-2-SBL
999 _c100026
_d100026