000 04172nam a22004935i 4500
001 978-94-007-7500-8
003 DE-He213
005 20140220082944.0
007 cr nn 008mamaa
008 140127s2013 ne | s |||| 0|eng d
020 _a9789400775008
_9978-94-007-7500-8
024 7 _a10.1007/978-94-007-7500-8
_2doi
050 4 _aQH301-705
072 7 _aPSA
_2bicssc
072 7 _aSCI086000
_2bisacsh
082 0 4 _a570
_223
100 1 _aSigel, Astrid.
_eeditor.
245 1 0 _aInterrelations between Essential Metal Ions and Human Diseases
_h[electronic resource] /
_cedited by Astrid Sigel, Helmut Sigel, Roland K.O. Sigel.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aXXXVII, 573 p. 103 illus., 28 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMetal Ions in Life Sciences,
_x1559-0836 ;
_v13
505 0 _aMetal Ions and Infectious Diseases. An Overview from the Clinic -- Sodium and Potassium in Health and Disease -- Magnesium in Health and Disease -- Calcium in Health and Disease -- Vanadium. Its Role for Humans -- Chromium: Is It Essential, Pharmacologically Relevant or Toxic?- Manganese in Health and Disease -- Iron: Effect of Deficiency and Overload -- Cobalt: Its Role in Health and Disease -- Nickel and Human Health -- Copper: Effects of Deficiency and Overload -- Zinc and Human Disease -- Molybdenum in Human Health and Disease -- Silicon: The Health Benefits of a Metalloid -- Arsenic. Can this Toxic Metalloid Sustain Life? -- Selenium. Role of the Essential Metalloid in Health.
520 _aMILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.
650 0 _aLife sciences.
650 0 _aMedicine.
650 0 _aChemistry.
650 1 4 _aLife Sciences.
650 2 4 _aLife Sciences, general.
650 2 4 _aBiomedicine general.
650 2 4 _aChemistry/Food Science, general.
700 1 _aSigel, Helmut.
_eeditor.
700 1 _aSigel, Roland K.O.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400774995
830 0 _aMetal Ions in Life Sciences,
_x1559-0836 ;
_v13
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-7500-8
912 _aZDB-2-SBL
999 _c100013
_d100013