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Systems Analysis of Human Multigene Disorders [electronic resource] / edited by Natalia Maltsev, Andrey Rzhetsky, T. Conrad Gilliam.

By: Maltsev, Natalia [editor.].
Contributor(s): Rzhetsky, Andrey [editor.] | Gilliam, T. Conrad [editor.] | SpringerLink (Online service).
Material type: materialTypeLabelBookSeries: Advances in Experimental Medicine and Biology: 799Publisher: New York, NY : Springer New York : Imprint: Springer, 2014Description: XIII, 122 p. 12 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9781461487784.Subject(s): Medicine | Human genetics | Biological models | Biomedicine | Biomedicine general | Systems Biology | Human GeneticsDDC classification: 610 Online resources: Click here to access online
Contents:
Wellness and Health Omics Linked to the Environment: the WHOLE approach to personalized medicine -- Characterizing Multi-omic Data in Systems Biology -- High-throughput Translational Medicine: Challenges and Solutions -- Computational approaches for human disease gene prediction and ranking -- A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization -- Index.
In: Springer eBooksSummary: Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.
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Wellness and Health Omics Linked to the Environment: the WHOLE approach to personalized medicine -- Characterizing Multi-omic Data in Systems Biology -- High-throughput Translational Medicine: Challenges and Solutions -- Computational approaches for human disease gene prediction and ranking -- A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization -- Index.

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

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