Humbert, Marc. creator editor. Evgenov, Oleg V. editor. Stasch, Johannes-Peter. editor. SpringerLink (Online service) text gw 2013 monographic eng

electronic

electronic resource

access IX, 576 p. 66 illus., 56 illus. in color. online resource. Preface.- Part I. Pulmonary hypertension: conceptual bases of the disease. Pulmonary hypertension: definition, classification, and epidemiology. Pulmonary hypertension: pathophysiology and signalling pathways. Pulmonary hypertension: pathology. Pulmonary hypertension: biomarkers. Pulmonary hypertension: animal models -- Part II. Pulmonary hypertension: established therapies. General supportive care. Calcium channel blockers. Prostacyclins. Endothelin receptor antagonists. Phosphodiesterase 5 inhibitors -- Part III. Pulmonary hypertension: novel pathways and emerging therapies     Soluble guanylate cyclase stimulators. Therapeutics targeting dysregulated redox equilibrium and endothelial dysfunction (NOXs, sGC activators, GSNOR). Rho-kinase inhibitors. Serotonin transporters and serotonin receptors. PDGF inhibitors. Novel anti-proliferative strategies beyond imatinib. Immunosuppressive agents. Vasoactive peptides. Inhibitors of cGMP/cAMP metabolism (MRP4, MRP5, PDE1). Old targets re-visited. Stem cells and cell based therapy -- Part IV. Conclusions and Outlook. Pulmonary hypertension: evidence-based management in the modern era and future directions. edited by Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch. Medicine Medical laboratories Toxicology Pharmaceutical technology Internal medicine Pneumology Biomedicine Pharmacology/Toxicology Pharmaceutical Sciences/Technology Internal Medicine Pneumology/Respiratory System Laboratory Medicine Molecular Medicine RM1-950 615 9783642386640 http://dx.doi.org/10.1007/978-3-642-38664-0 http://dx.doi.org/10.1007/978-3-642-38664-0 131004 20140220082912.0 978-3-642-38664-0