Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing [electronic resource] / edited by Charles E. Samuel.
By: Samuel, Charles E [editor.].
Contributor(s): SpringerLink (Online service).
Material type:
BookSeries: Current Topics in Microbiology and Immunology: 353Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 2012Description: X, 238 p. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783642228018.Subject(s): Medicine | Human physiology | Biomedicine | Molecular Medicine | Human PhysiologyDDC classification: 611.01816 Online resources: Click here to access online
In:
Springer eBooksSummary: The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.
The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.
There are no comments for this item.