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Infection, Immune Homeostasis and Immune Privilege [electronic resource] / edited by Joan Stein-Streilein.

By: Stein-Streilein, Joan [editor.].
Contributor(s): SpringerLink (Online service).
Material type: materialTypeLabelBookSeries: Birkhäuser Advances in Infectious Diseases: Publisher: Basel : Springer Basel : Imprint: Springer, 2012Description: XI, 153 p. 12 illus., 7 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783034804455.Subject(s): Medicine | Microbiology | Biomedicine | Molecular Medicine | Medical MicrobiologyDDC classification: 611.01816 Online resources: Click here to access online
Contents:
Introduction -- The Eye as Immune Privileged Site -- Immune Privilege of the Testis – Meaning, Mechanisms and Manifestations -- The Role of Intrauterine Immune Privilege in Perinatal Infectious Diseases -- The Liver as an Immune Privileged Site -- Immune Homeostasis of the Lung: The Role of Regulatory NKT Cells in Asthma -- Immune Homeostasis of the Gut.
In: Springer eBooksSummary: Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated “immune-privileged sites” by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms. This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.
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Introduction -- The Eye as Immune Privileged Site -- Immune Privilege of the Testis – Meaning, Mechanisms and Manifestations -- The Role of Intrauterine Immune Privilege in Perinatal Infectious Diseases -- The Liver as an Immune Privileged Site -- Immune Homeostasis of the Lung: The Role of Regulatory NKT Cells in Asthma -- Immune Homeostasis of the Gut.

Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated “immune-privileged sites” by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms. This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.

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