TGF-β in Human Disease (Record no. 99089)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04407nam a22004815i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-4-431-54409-8 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20140220082927.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 130619s2013 ja | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9784431544098 |
| -- | 978-4-431-54409-8 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-4-431-54409-8 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QR185.8.C95 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | PSF |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | SCI007000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | SCI017000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 572.6 |
| Edition number | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Moustakas, Aristidis. |
| Relator term | editor. |
| 245 10 - TITLE STATEMENT | |
| Title | TGF-β in Human Disease |
| Medium | [electronic resource] / |
| Statement of responsibility, etc | edited by Aristidis Moustakas, Keiji Miyazawa. |
| 264 #1 - | |
| -- | Tokyo : |
| -- | Springer Japan : |
| -- | Imprint: Springer, |
| -- | 2013. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | VIII, 464 p. 39 illus., 32 illus. in color. |
| Other physical details | online resource. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Part I Introduction -- 1 Transforming Growth Factor-β Signaling -- 2 TGF-β Signaling in Stem Cell Fate Determination -- 3 Emerging Roles of TGF-β Co-receptors in Human Disease -- Part II Cancer, Fibrosis, and Inflammation -- 4 TGF-β in Cancer Stem Cells -- 5 TGF-β as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition -- 6 TGF-β as Tumor Suppressor: Lessons from Mouse Models -- 7 The Multifunctional Roles of TGF-β in Navigating the Metastatic Cascade -- 8 TGF-β Signaling in Leukemogenesis -- 9 TGF-β in Skin Cancer and Fibrosis -- 10 The Role of TGF-β in Cutaneous Melanoma Biology -- 11 The Transforming Growth Factor-Beta (TGF-β) in Liver Fibrosis -- 12 TGF-β and Inhibitory Smads in Inflammation -- Part III Cardiovascular Diseases -- 13 TGF-β and Cardiovascular Disorders -- 14 TGF-β Signaling in Physiological and Pathological Angiogenesis -- 15 TGF-β Signaling Pathway and MicroRNAs in Cardiovascular Disease -- Part IV Other Diseases -- 16 TGF-β and Genetic Skeletal Diseases -- 17 TGF-β in Brain Disorders -- 18 TGF-β and Metabolic Homeostasis -- Part V Disease Prognosis and Therapy. 19 Targeting Pro-Angiogenic TGF-β Signaling in the Tumor Microenvironment. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Transforming growth factor-β (TGF-β) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-β now is rather well understood. Continuing revelations in the mechanisms of action of TGF-β provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse diseases. Equally important, however, is the current promise of exploiting the TGF-β pathway in combating human disease. This book comprehensively covers major areas of human disease where the involvement of TGF-β is firmly established. Simultaneously, the book highlights major gaps in knowledge and the future directions of research that can benefit human medical science. The core set of diseases where TGF-β action is well documented and are included in the book are cancer and cardiovascular and fibrotic disorders. The central aim of the book is to stimulate young scientists to enter the prolific TGF-β field and find new solutions to the problems remaining in this area of study. For this purpose the book provides authoritative educational chapters that furnish a good introduction to the field for young doctoral students, postdocs, and clinical fellows. The book also serves as a valuable reference for the aficionados in the field, who can find accessible and well-illustrated material for their teaching and lecturing activities, via which the importance of TGF-β biology is disseminated to the world of science and to the public. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Life sciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Oncology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cytokines. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cytology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Life Sciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cytokines and Growth Factors. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cell Biology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cancer Research. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Miyazawa, Keiji. |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9784431544081 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://dx.doi.org/10.1007/978-4-431-54409-8 |
| 912 ## - | |
| -- | ZDB-2-SBL |
No items available.