Vesicle Trafficking in Cancer (Record no. 95693)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04086nam a22005175i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-1-4614-6528-7 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20140220082825.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 130403s2013 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781461465287 |
| -- | 978-1-4614-6528-7 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-1-4614-6528-7 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RC261-271 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCL |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED062000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 614.5999 |
| Edition number | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Yarden, Yosef. |
| Relator term | editor. |
| 245 10 - TITLE STATEMENT | |
| Title | Vesicle Trafficking in Cancer |
| Medium | [electronic resource] / |
| Statement of responsibility, etc | edited by Yosef Yarden, Gabi Tarcic. |
| 264 #1 - | |
| -- | New York, NY : |
| -- | Springer New York : |
| -- | Imprint: Springer, |
| -- | 2013. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | XIV, 393 p. 50 illus., 47 illus. in color. |
| Other physical details | online resource. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Preface -- Clathrin Mediated Endocytosis -- Intimate And Facultative? Regulation Of Clathrin-Mediated Endocytosis By The Actin Cytoskeleton -- Oncogenic Signaling From The Plasma Membrane -- Endocytosis In The Spatial Control Of Polarized Cell Functions -- Aberrant Vesicular Trafficking Contributes To Altered Polarity And Metabolism In Cancer -- Endocytosis And The Regulation Of Cell Signaling, Cell Adhesion, And Epithelial To Mesenchymal Transition In Cancer -- Efficient Enhancement Of Signaling Capacity: Signaling Endosomes -- Nuclear Functions And Trafficking Of Receptor Tyrosine Kinases -- Efficient Enhancement Of Signaling Capacity – The Ubiquitin System.- Molecular Mechanism Of Ubiquitin-Dependent Traffic -- Cbl As A Master Regulator Of Receptor Tyrosine Kinase Trafficking -- Regulation Of Endocytic Trafficking And Signaling By Deubiquitylating Enzymes -- RTKs As Models For Trafficking Regulation - C-Met/HGF-Receptor- C-Met Signalling In Cancer: Location Counts -- Regulation Of Epidermal Growth Factor Receptor Signaling By Endocytosis In Normal And Malignant Cells -- Stress-Driven Endocytosis Of Tyrosine-Phosphorylated EGFR Leads To Tumorigenesis: The Critical Role Of Oxidative Stress -- Internalisation, Endosomal Trafficking And Recycling Of Integrins During Cell Migration And Cancer Invasion -- Antibody-mediated receptor endocytosis: Harnessing the cellular machinery to combat cancer -- Index. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Endocytosis and vesicular trafficking determine the landscape of the cell’s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Oncology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biochemistry. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Post-translational modification of proteins. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cell receptors. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cytology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cancer Research. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cell Biology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biochemistry, general. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Posttranslational Modification. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Receptors. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarcic, Gabi. |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9781461465270 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://dx.doi.org/10.1007/978-1-4614-6528-7 |
| 912 ## - | |
| -- | ZDB-2-SBL |
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