Systems Biology of Metabolic and Signaling Networks (Record no. 93249)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 04470nam a22005655i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-3-642-38505-6 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20140220082518.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 131021s2014 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783642385056 |
| -- | 978-3-642-38505-6 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-3-642-38505-6 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QH301-705 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | PSA |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | SCI086000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | SCI064000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 570 |
| Edition number | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aon, Miguel A. |
| Relator term | editor. |
| 245 10 - TITLE STATEMENT | |
| Title | Systems Biology of Metabolic and Signaling Networks |
| Medium | [electronic resource] : |
| Remainder of title | Energy, Mass and Information Transfer / |
| Statement of responsibility, etc | edited by Miguel A. Aon, Valdur Saks, Uwe Schlattner. |
| 264 #1 - | |
| -- | Berlin, Heidelberg : |
| -- | Springer Berlin Heidelberg : |
| -- | Imprint: Springer, |
| -- | 2014. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | X, 375 p. 90 illus., 67 illus. in color. |
| Other physical details | online resource. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Springer Series in Biophysics, |
| International Standard Serial Number | 0932-2353 ; |
| Volume number/sequential designation | 16 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | I Introduction -- From Physiology, Genomes, Systems and Self-Organization to Systems Biology: The Historical Roots of a 21st Century Approach to Complexity -- Systems Biology of Networks: The Riddle and the Challenge -- II Systems Biology of Signaling Networks -- Micrornas and Robustness In Biological Regulatory Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic And Genetic -- Dynamics of Mitochondrial Redox and Energy Networks: Insights from an Experimental-Computational Synergy -- Adenylate Kinase Isoform Network: A Major Hub in Cell Energetics and Metabolic Signaling -- The Control Analysis of Signal Transduction -- III Systems Biology of Cellular Structures and Fluxes -- Moonlighting Function of the Tubulin Cytoskeleton -- Metabolic Dissipative Structures -- Systems Biology Approaches to Cancer Energy Metabolism -- IV Systems Biology of Organ Function -- Network Dynamics in Cardiac Electrophysiology -- Systems Level Regulation of Energy Fluxes via Metabolic Cycles. Role of Creatine and Phosphotransfer Pathways -- V Systems Biology of Microorganisms -- Temporal Partitioning of the Yeast Cellular Network -- Systems Biology and Metabolic Engineering in Bacteria. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Life sciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Proteomics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biological models. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Metabolism. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biology |
| General subdivision | Data processing. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Life Sciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Systems Biology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Computer Appl. in Life Sciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biological Networks, Systems Biology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Metabolomics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Proteomics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biophysics and Biological Physics. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Saks, Valdur. |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Schlattner, Uwe. |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9783642385049 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Springer Series in Biophysics, |
| -- | 0932-2353 ; |
| Volume number/sequential designation | 16 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://dx.doi.org/10.1007/978-3-642-38505-6 |
| 912 ## - | |
| -- | ZDB-2-SBL |
No items available.