Patient specific stem cells / (Record no. 126986)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04572cam a2200373Ii 4500 |
| 001 - CONTROL NUMBER | |
| control field | 9781315402185 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180420s2017 fluab ob 001 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781315402185 |
| -- | (e-book: PDF) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781315405742 |
| -- | (e-book) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781466580299 |
| -- | (e-book) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| Cancelled/invalid ISBN | 9781466580268 |
| -- | (hardback) |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1201/b21629 |
| Source of number or code | doi |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | (OCoLC)972609986 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | FlBoTFG |
| Transcribing agency | FlBoTFG |
| Description conventions | rda |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QH588.S83 |
| 060 10 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | QU 325 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED |
| Subject category code subdivision | 009000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | SCI |
| Subject category code subdivision | 010000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | TCB |
| Source | bicscc |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.02/774 |
| Edition number | 23 |
| 245 00 - TITLE STATEMENT | |
| Title | Patient specific stem cells / |
| Statement of responsibility, etc | edited by Deepak A. Lamba. |
| 264 #1 - | |
| -- | Boca Raton, FL : |
| -- | CRC Press, an imprint of Taylor and Francis, |
| -- | 2017. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (292 pages) : |
| Other physical details | 79 illustrations |
| 336 ## - | |
| -- | text |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | rdacarrier |
| 505 00 - FORMATTED CONTENTS NOTE | |
| Title | Preface -- |
| -- | About the Editor -- |
| -- | Contributors -- |
| -- | 1. Human-Induced Pluripotent Stem Cells: Derivation / |
| Statement of responsibility | Uthra Rajamani, Lindsay Lenaeus, Loren Ornelas, and Dhruv Sareen -- |
| Title | 2. Human-Induced Pluripotent Stem Cells: Banking and Characterization / |
| Statement of responsibility | Uthra Rajamani, Lindsay Lenaeus, Loren Ornelas, and Dhruv Sareen -- |
| Title | 3. Genetic and Epigenetic Considerations in iPSC Technology / |
| Statement of responsibility | Yoshiaki Tanaka and In-Hyun Park -- |
| Title | 4. CRISPR-Based Genome Engineering in Human Stem Cells / |
| Statement of responsibility | Thelma Garcia and Deepak A. Lamba -- |
| Title | 5. Stem Cells for Parkinson's Disease / |
| Statement of responsibility | Deepak A. Lamba -- |
| Title | 6. Huntington's Disease and Stem Cells / |
| Statement of responsibility | Karen Ring, Robert O'Brien, Ningzhe Zhang, and Lisa M. Ellerby -- |
| Title | 7. Applications of Pluripotent Stem Cells in the Therapy and Modeling of Diabetes and Metabolic Diseases / |
| Statement of responsibility | Suranjit Mukherjee and Shuibing Chen -- |
| Title | 8. Role of iPSCs in Disease Modeling: Gaucher Disease and Related Disorders / |
| Statement of responsibility | Daniel K. Borger, Elma Aflaki, and Ellen Sidransky -- |
| Title | 9. Role of Induced Pluripotent Stem Cells in Urological Disease Modeling and Repair / |
| Statement of responsibility | Mohammad Moad, Emma L. Curry, Craig N. Robson, and Rakesh Heer -- |
| Title | 10. Induced Pluripotent Stem Cells: A Research Tool and a Potential Therapy for RPE-Associated Blinding Eye Diseases / |
| Statement of responsibility | Ruchi Sharma, Balendu Shekhar Jha, and Kapil Bharti -- |
| Title | 11. Modeling Neuroretinal Development and Disease in Stem Cells / |
| Statement of responsibility | Deepak A. Lamba -- |
| Title | Index. |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc | One of the biggest challenges faced in medical research had been to create accurate and relevant models of human disease. A number of good animal models have been developed to understand the pathophysiology. However, not all of them reflect the human disorder, a classic case being Usher's syndrome where the mutant mice do not have the same visual and auditory defects that patients face. There are others which have been even more difficult to model due to the multi-factorial nature of the condition and due to lack of discovery of a single causative gene such as age-related macular degeneration or Alzheimer's syndrome. Thus a more relevant and accurate system will allow us to make better predictions on relevant therapeutic approaches. The discovery of human pluripotent stem cells in 1998 followed by the technological advances to reprogram somatic cells to pluripotent-stem cell-like cells in 2006 has completely revolutionized the way we can now think about modelling human development and disease. This now coupled with genome editing technologies such as TALENS and CRISPRs have now set us up to develop in vitro models both 2D as well as 3D organoids, which can more precisely reflect the disease in the patients. These combinatorial technologies are already providing us with better tools and therapeutics in drug discovery or gene therapy. This book summarizes both the technological advances in the field of generation of patient specific lines as well as various gene editing approaches followed by its applicability in various systems. The book will serve as a reference for the current state of the field as it: -Provides a comprehensive overview of the status of the field of patients derived induced pluripotent stem cells.-Describes the use of cardiac cells as a main featured component within the book.-Examines drug toxicity analysis as a working example throughout the book. |
| 650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Pluripotent Stem Cells |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | SCIENCE / Biotechnology. |
| Source of heading or term | bisacsh |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamba, Deepak Ashok |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Taylor and Francis. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Print version: |
| International Standard Book Number | 9781466580268 |
| Record control number | (DLC) 2016039660 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | https://www.taylorfrancis.com/books/9781315402185 |
| Public note | Click here to view. |
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