Diabetes, Insulin and Alzheimer's Disease (Record no. 111588)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04480nam a22004935i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-3-642-04300-0 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20140220084526.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 100316s2010 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783642043000 |
| -- | 978-3-642-04300-0 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-3-642-04300-0 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RC321-580 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | PSAN |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED057000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 612.8 |
| Edition number | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Craft, Suzanne. |
| Relator term | editor. |
| 245 10 - TITLE STATEMENT | |
| Title | Diabetes, Insulin and Alzheimer's Disease |
| Medium | [electronic resource] / |
| Statement of responsibility, etc | edited by Suzanne Craft, Yves Christen. |
| 264 #1 - | |
| -- | Berlin, Heidelberg : |
| -- | Springer Berlin Heidelberg, |
| -- | 2010. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | XIII, 250p. 30 illus., 21 illus. in color. |
| Other physical details | online resource. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Research and Perspectives in Alzheimer's Disease, |
| International Standard Serial Number | 0945-6066 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Insulin Action in the Brain and the Pathogenesis of Alzheimer’s Disease -- The Brain-insulin Connection, Metabolic Diseases and Related Pathologies -- Insulin-Mediated Neuroplasticity in the Central Nervous System -- Stress Hormones and Neuroplasticity in the Diabetic Brain -- Diabetes and the Brain – An Epidemiologic Perspective -- Cognition in Type 2 Diabetes: Brain Imaging Correlates and Vascular and Metabolic Risk Factors -- The Relationship Between the Continuum of Elevated Adiposity, Hyperinsulinemia, and Type 2 Diabetes and Late-onset Alzheimer’s Disease: An Epidemiological Perspective -- The Role of Insulin Dysregulation in Aging and Alzheimer’s Disease -- Is Alzheimer’s a Disorder of Ageing and Why Don’t Mice get it? The Centrality of Insulin Signalling to Alzheimer’s Disease Pathology -- PKC and Insulin Pathways in Memory Storage: Targets for Synaptogenesis, Anti-apoptosis, and the Treatment of AD -- Diet, Abeta Oligomers and Defective Insulin and Neurotrophic Factor Signaling in Alzheimer’s Disease -- Serum IGF-I, Life Style, and Risk of Alzheimer’s disease. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Neurons share more similarities with insulin-producing pancreatic islet cells than with any other cell type. The root of this similarity may lie in the islet’s evolution from an ancestral insulin-producing neuron. The islet-neuron connection becomes less surprising as we learn more about insulin’s involvement in functions far from its traditional role in mediating glucose uptake in muscle. The importance of insulin in the regulation of corporal aging has been established by the dramatic increases in longevity experienced by animals in which the adipose insulin receptor has been genetically eliminated, or in which the insulin-related daf genes have been mutated. New research suggests that, analogous to its influence on corporal aging, insulin also makes important contributions to brain aging and the expression of late-life neurodegenerative disease. Insulin plays a key role in cognition and other aspects of normal brain function. Insulin resistance induces chronic peripheral insulin elevations and is associated with reduced insulin activity both in periphery and brain. The insulin resistance syndrome underlies conditions such as Type 2 diabetes mellitus and hypertension, which are associated with age-related cognitive impairment and Alzheimer’s disease. This book discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease. Given the recent pandemic of conditions associated with insulin resistance, it is imperative that we achieve a comprehensive knowledge of the mechanisms through which insulin resistance affects brain function in order to develop therapeutic strategies to address these effects. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Neurosciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Geriatrics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Endocrinology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Neurosciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Endocrinology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Geriatrics/Gerontology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Christen, Yves. |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9783642042997 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Research and Perspectives in Alzheimer's Disease, |
| -- | 0945-6066 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://dx.doi.org/10.1007/978-3-642-04300-0 |
| 912 ## - | |
| -- | ZDB-2-SBL |
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