Advances in Mitochondrial Medicine (Record no. 104594)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 05164nam a22005295i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-94-007-2869-1 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20140220083343.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 120308s2012 ne | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9789400728691 |
| -- | 978-94-007-2869-1 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-94-007-2869-1 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | R-RZ |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MBGR |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED000000 |
| Source | bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610 |
| Edition number | 23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Scatena, Roberto. |
| Relator term | editor. |
| 245 10 - TITLE STATEMENT | |
| Title | Advances in Mitochondrial Medicine |
| Medium | [electronic resource] / |
| Statement of responsibility, etc | edited by Roberto Scatena, Patrizia Bottoni, Bruno Giardina. |
| 264 #1 - | |
| -- | Dordrecht : |
| -- | Springer Netherlands, |
| -- | 2012. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | XII, 461p. 62 illus., 28 illus. in color. |
| Other physical details | online resource. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Advances in Experimental Medicine and Biology, |
| International Standard Serial Number | 0065-2598 ; |
| Volume number/sequential designation | 942 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Section I – Physiology and structure of Mitochondria -- 1. The oxidative phosphorylation system in mammalian mitochondria -- 2. Physiology and pathophysiology of mitochondrial DNA -- 3. Mitochondrial calcium as a key regulator of mitochondrial activities -- 4. Mitochondria and Nitric Oxide: Chemistry and Pathophysiology -- 5. Mitochondria and reactive oxygen species - which role in physiology and pathophysiology? -- 6. Uncoupling proteins: molecular, functional, regulatory, physiological and pathological aspects -- 7. The mitochondrial pathways of apoptosis -- Section II – Mitochondria and disease -- 8. Inherited mitochondrial disorders -- 9. Mitochondria and metabolism diseases -- 10. Mitochondria and diabetes. An intriguing pathogenetic role -- 11. Mitochondria and heart diseases -- 12. Mitochondria in neurodegeneration -- 13. Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation -- Section III – Mitochondria and Aging -- 14.Mitochondria and aging -- 15. Mitochondria and pharmacology. -16. Iatrogenic mitochondriopathies: a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors -- 17. Dysfunction of mitochondrial respiratory chain complex I in neurological disorders: genetics and pathogenetic mechanisms -- 18. Anthracyclines and mitochondria -- Section IV- Applications of Mitochondrial science -- 19. Mitochondrial proteomics approaches for new potential diagnostic and prognostic biomarkers in cancer -- 20. Mitochondria in Anthropology and forensic medicine. . |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Oncology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Toxicology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biochemistry. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Biomedicine general. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cancer Research. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Molecular Medicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Pharmacology/Toxicology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Medical Biochemistry. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Bottoni, Patrizia. |
| Relator term | editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Giardina, Bruno. |
| Relator term | editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Display text | Printed edition: |
| International Standard Book Number | 9789400728684 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Advances in Experimental Medicine and Biology, |
| -- | 0065-2598 ; |
| Volume number/sequential designation | 942 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://dx.doi.org/10.1007/978-94-007-2869-1 |
| 912 ## - | |
| -- | ZDB-2-SBL |
No items available.