Gurevich, Vsevolod V.
Arrestins - Pharmacology and Therapeutic Potential [electronic resource] / edited by Vsevolod V. Gurevich. - VIII, 447 p. 53 illus., 42 illus. in color. online resource. - Handbook of Experimental Pharmacology, 219 0171-2004 ; . - Handbook of Experimental Pharmacology, 219 .
Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia.
This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
9783642411991
10.1007/978-3-642-41199-1 doi
Medicine.
Gene therapy.
Toxicology.
Biochemistry.
Cell receptors.
Cytology.
Biomedicine.
Pharmacology/Toxicology.
Biochemistry, general.
Protein Structure.
Gene Therapy.
Cell Physiology.
Receptors.
RM1-950
615
Arrestins - Pharmacology and Therapeutic Potential [electronic resource] / edited by Vsevolod V. Gurevich. - VIII, 447 p. 53 illus., 42 illus. in color. online resource. - Handbook of Experimental Pharmacology, 219 0171-2004 ; . - Handbook of Experimental Pharmacology, 219 .
Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors -- Arrestin-biased GPCR Agonists -- Arrestin-1 Expression Levels, Rod Function and Health -- Protective Functions of Arrestin-1 in Photoreceptors -- Arrestin-4 and Cone Function -- Enhanced Phosphorylation-independent Arrestins and Gene Therapy -- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking -- Arrestins in Ubiquitination and Deubiquitination -- Arrestin Self-association -- Arrestin-dependent Activation of ERK and Src -- Arrestin-dependent Activation of JNK Family Kinases -- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization -- Arrestins in Cell Migration -- Arrestins in Host-pathogen Interactions -- Arrestin Regulation of Small GTPases -- GPCRs and Arrestins in Airways: Implications for Asthma -- Arrestins as Regulatory Signaling Hubs in Cancer Pathways -- Arrestins in Pain and Anesthesia.
This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
9783642411991
10.1007/978-3-642-41199-1 doi
Medicine.
Gene therapy.
Toxicology.
Biochemistry.
Cell receptors.
Cytology.
Biomedicine.
Pharmacology/Toxicology.
Biochemistry, general.
Protein Structure.
Gene Therapy.
Cell Physiology.
Receptors.
RM1-950
615