Francis, Sharron H.
Phosphodiesterases as Drug Targets [electronic resource] / edited by Sharron H. Francis, Marco Conti, Miles D. Houslay. - XVIII, 522 p. online resource. - Handbook of Experimental Pharmacology, 204 0171-2004 ; . - Handbook of Experimental Pharmacology, 204 .
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
9783642179693
10.1007/978-3-642-17969-3 doi
Medicine.
Toxicology.
Biochemistry.
Enzymes.
Post-translational modification of proteins.
Cytology.
Biomedicine.
Pharmacology/Toxicology.
Medicinal Chemistry.
Protein Structure.
Enzymology.
Posttranslational Modification.
Cell Physiology.
RM1-950
615
Phosphodiesterases as Drug Targets [electronic resource] / edited by Sharron H. Francis, Marco Conti, Miles D. Houslay. - XVIII, 522 p. online resource. - Handbook of Experimental Pharmacology, 204 0171-2004 ; . - Handbook of Experimental Pharmacology, 204 .
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
9783642179693
10.1007/978-3-642-17969-3 doi
Medicine.
Toxicology.
Biochemistry.
Enzymes.
Post-translational modification of proteins.
Cytology.
Biomedicine.
Pharmacology/Toxicology.
Medicinal Chemistry.
Protein Structure.
Enzymology.
Posttranslational Modification.
Cell Physiology.
RM1-950
615